a gene that directs the regeneration of injured muscle from adult stem cells基因指导受伤的肌肉从成体干细胞的再生.pdfVIP
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a gene that directs the regeneration of injured muscle from adult stem cells基因指导受伤的肌肉从成体干细胞的再生
Research Digest
Synopses of Research Articles
Depositing a Histone That Protects Active Chromosomal Regions from Silencing
When James Watson and Francis function depends largely on activating SWR1-Com. The largest subunit of this
Crick reported the structure of DNA in the right gene at the right time, complex, called Swr1p, belongs to a well-
1953, the mechanism of inheritance was mechanisms have evolved that protect known family of adenosine triphosphate
instantly apparent. The complementary active genes from the intrusions of (ATP)-dependent chromatin remodeling
pairing of the DNA bases in the silencing structures like heterochromatin. enzymes (they use the energy of ATP to
double helix, the pair famously wrote, power remodeling) that provide access
“immediately suggests a possible to DNA in chromatin. Rine, Madhani, and
copying mechanism for the genetic colleagues show that protein subunits of
material.’’ The structure helped explain SWR1-Com associate specifi cally with the
one of the central problems of modern histone variant H2A.Z. By comparing the
biology: how does genetic material get gene expression profi les of yeast mutants
faithfully replicated and then passed on lacking the H2A.Z-encoding gene with
from generation to generation? It was mutants l
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