a genetic variant in mir-196a2 increased digestive system cancer risks a meta-analysis of 15 case-control studiesmir - 196基因变异u2014u2014a2消化系统癌症的风险增加15个病例对照研究的荟萃分析.pdfVIP

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2017-09-05 发布于上海
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a genetic variant in mir-196a2 increased digestive system cancer risks a meta-analysis of 15 case-control studiesmir - 196基因变异u2014u2014a2消化系统癌症的风险增加15个病例对照研究的荟萃分析.pdf

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a genetic variant in mir-196a2 increased digestive system cancer risks a meta-analysis of 15 case-control studiesmir - 196基因变异u2014u2014a2消化系统癌症的风险增加15个病例对照研究的荟萃分析

A Genetic Variant in miR-196a2 Increased Digestive System Cancer Risks: A Meta-Analysis of 15 Case-Control Studies Jing Guo, Mingjuan Jin, Mingwu Zhang, Kun Chen* Department of Epidemiology and Health Statistics, School of Public Health, Zhejiang University, Hangzhou, Zhejiang, China Abstract Background: MicroRNAs (miRNAs) negatively regulate the gene expression and act as tumor suppressors or oncogenes in oncogenesis. The association between single nucleotide polymorphism (SNP) in miR-196a2 r and the susceptibility of digestive system cancers was inconsistent in previous studies. Methodology/Principal Findings: An updated meta-analysis based on 15 independent case-control studies consisting of 4999 cancer patients and 7606 controls was performed to address this association. It was found that miR-196a2 polymorphism significantly elevated the risks of digestive system cancers (CT vs. TT, OR = 1.25, 95% CI = 1.07–1.45; CC vs. TT, OR = 1.38, 95% CI = 1.13–1.67; CC/CT vs. TT, OR = 1.29, 95% CI = 1.10–1.50; CC vs. CT/TT, OR = 1.14, 95% CI = 1.01–1.30; C vs. T, OR = 1.15, 95% CI = 1.05–1.26). We also found that variant in miR-196a2 increased the susceptibility of colorectal cancer (CRC) (CT vs. TT, OR = 1.23, 95% CI = 1.04–1.44; CC vs. TT, OR = 1.32, 95% CI = 1.08–1.61; CC/CT vs. TT, OR = 1.25, 95% CI = 1.07–1.46; C vs. T, OR = 1.15, 95% CI = 1.05–1.28), while the association in recessive model (CC vs. CT/TT, OR = 1.16, 95% CI = 0.98–1.38) showed a marginal significance. Additionally, significant association between miR-196a2 polymorphism and increased risk of hepatocellular cancer (HCC) was detected. By stratifying tumors on the basis of site of origin, source of controls, ethnicity and allele frequency in controls, elevated cancer risks were observed. Conclu