a genetic variant in the il-17 promoter is functionally associated with acute graft-versus-host disease after unrelated bone marrow transplantationil-17启动子功能相关的基因变异不相关的骨髓移植后急性移植物抗宿主病.pdfVIP

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a genetic variant in the il-17 promoter is functionally associated with acute graft-versus-host disease after unrelated bone marrow transplantationil-17启动子功能相关的基因变异不相关的骨髓移植后急性移植物抗宿主病.pdf

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a genetic variant in the il-17 promoter is functionally associated with acute graft-versus-host disease after unrelated bone marrow transplantationil-17启动子功能相关的基因变异不相关的骨髓移植后急性移植物抗宿主病

A Genetic Variant in the IL-17 Promoter Is Functionally Associated with Acute Graft-Versus-Host Disease after Unrelated Bone Marrow Transplantation 1 1 1 2 3 J. Luis Espinoza , Akiyoshi Takami *, Katsuya Nakata , Makoto Onizuka , Takakazu Kawase , Hideki 4 5 3 6 7 1 Akiyama , Koichi Miyamura , Yasuo Morishima , Takahiro Fukuda , Yoshihisa Kodera , Shinji Nakao for the Japan Marrow Donor Program 1 Department of Hematology and Oncology, Kanazawa University Hospital, Kanazawa, Japan, 2 Department of Hematology and Oncology, Tokai University School of Medicine, Isehara, Japan, 3 Division of Epidemiology and Prevention, Aichi Cancer Research Center, Nagoya, Japan, 4 Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan, 5 Department of Hematology, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan, 6 Hematopoietic Stem Cell Transplantation Unit, National Cancer Center Hospital, Tokyo, Japan, 7 Department of Promotion for Blood and Marrow Transplantation, Aichi Medical University, Nagoya, Japan Abstract Interleukin IL-17 is a proinflammatory cytokine that has been implicated in the pathogenesis of various autoimmune diseases. The single nucleotide polymorphism (SNP), rs2275913, in the promoter region of the IL-17 gene is associated with susceptibility to ulcerative colitis. When we examined the impact of rs2275913 in a cohort consisting of 438 pairs of patients and their unrelated donors transplanted through the Japan Marrow Donor Program, the donor IL-17 197A allele was found to be associated with a higher risk of acute graft-versus-host d