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a genome-wide analysis of small regulatory rnas in the human pathogen group a streptococcus小的全基因组分析监管rna在人类病原体a群链球菌
A Genome-Wide Analysis of Small Regulatory RNAs in
the Human Pathogen Group A Streptococcus
1 ˜ 1 1 1 2 1
Nataly Perez , Jeanette Trevino , Zhuyun Liu , Siu Chun Michael Ho , Paul Babitzke , Paul Sumby *
1 Center for Molecular and Translational Human Infectious Diseases Research, The Methodist Hospital Research Institute, Houston, Texas, United States of America,
2 Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America
Abstract
The coordinated regulation of gene expression is essential for pathogens to infect and cause disease. A recently appreciated
mechanism of regulation is that afforded by small regulatory RNA (sRNA) molecules. Here, we set out to assess the
prevalence of sRNAs in the human bacterial pathogen group A Streptococcus (GAS). Genome-wide identification of
candidate GAS sRNAs was performed through a tiling Affymetrix microarray approach and identified 40 candidate sRNAs
within the M1T1 GAS strain MGAS2221. Together with a previous bioinformatic approach this brings the number of novel
candidate sRNAs in GAS to 75, a number that approximates the number of GAS transcription factors. Transcripts were
confirmed by Northern blot analysis for 16 of 32 candidate sRNAs tested, and the abundance of several of these sRNAs were
shown to be temporally regulated. Six sRNAs were selected for further study and the promoter, transcriptional start site, and
Rho-independent terminator identified for each. Significant variation was observed between the six sRNAs with respect to
their stability during growth, and with respect to their inter- and/or intra-serotype-specific l
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