a genome-wide association study identifies ugt1a1 as a regulator of serum cell-free dna in young adults the cardiovascular risk in young finns studyugt1a1调节器的全基因组关联研究确定血清游离dna年轻人年轻芬兰人的心血管风险的研究.pdfVIP

A Genome-Wide Association Study Identifies UGT1A1 as a Regulator of Serum Cell-Free DNA in Young Adults: The Cardiovascular Risk in Young Finns Study ¨ ¨ 1 . ¨ 2. ¨ ¨ 3 ¨ ¨ 4 5 Juulia Jylhava * , Leo-Pekka Lyytikainen , Mika Kahonen , Nina Hutri-Kahonen , Johannes Kettunen , 6 7,8 ¨ 9 1,10 Jorma Viikari , Olli T. Raitakari , Terho Lehtimaki , Mikko Hurme 1 Department of Microbiology and Immunology, School of Medicine, University of Tampere, Tampere, Finland, 2 Department of Clinical Chemistry, School of Medicine, University of Tampere, Tampere, Finland, 3 Department of Clinical Physiology, University of Tampere and Tampere University Hospital, Tampere, Finland, 4 Department of Pediatrics, University of Tampere and Tampere University Hospital, Tampere, Finland, 5 Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland, 6 Department of Medicine, University of Turku and Turku University Hospital, Turku, Finland, 7 Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland, 8 Department of Clinical Physiology, University of Turku and Turku University Hospital, Turku, Finland, 9 Department of Clinical Chemistry, Tampere University Hospital, Tampere, Finland, 10 Department of Microbiology, Tampere University Hospital, Tampere, Finland Abstract Introduction: Circulating cell-free DNA (cf-DNA) is a useful indicator of cell death, and it can also be used to predict outcomes in various clinical disorders. Several innate immune mechanisms are known to be involved in eliminating DNA and chromatin-related