a genomic island in salmonella enterica ssp. salamae provides new insights on the genealogy of the locus of enterocyte effacement沙门氏菌血清ssp基因岛。.pdfVIP
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a genomic island in salmonella enterica ssp. salamae provides new insights on the genealogy of the locus of enterocyte effacement沙门氏菌血清ssp基因岛。
A Genomic Island in Salmonella enterica ssp. salamae
Provides New Insights on the Genealogy of the Locus of
Enterocyte Effacement
1 1 1 2 3
P. Scott Chandry *, Simon Gladman , Sean C. Moore , Torsten Seemann , Keith A. Crandall ,
Narelle Fegan1
1 CSIRO Division of Animal, Food and Health Sciences, Werribee, Victoria, Australia, 2 Victorian Bioinformatics Consortium, Monash University, Clayton, Victoria, Australia,
3 Computational Biology Institute, George Washington University, Ashburn, Virginia, United States of America
Abstract
The genomic island encoding the locus of enterocyte effacement (LEE) is an important virulence factor of the human
pathogenic Escherichia coli. LEE typically encodes a type III secretion system (T3SS) and secreted effectors capable of
forming attaching and effacing lesions. Although prominent in the pathogenic E. coli such as serotype O157:H7, LEE has also
been detected in Citrobacter rodentium, E. albertii, and although not confirmed, it is likely to also be in Shigella boydii.
Previous phylogenetic analysis of LEE indicated the genomic island was evolving through stepwise acquisition of various
components. This study describes a new LEE region from two strains of Salmonella enterica subspecies salamae serovar Sofia
along with a phylogenetic analysis of LEE that provides new insights into the likely evolution of this genomic island. The
Salmonella LEE contains 36 of the 41 genes typically observed in LEE within a genomic island of 49, 371 bp that encodes a
total of 54 genes. A phylogenetic analysis was performed on the entire T3SS and four T3SS genes (escF, escJ, escN, and escV)
to elucidate the genealogy of LEE. Phylogenetic analysis inferred that the previously known LEE isl
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