a gip receptor agonist exhibits β-cell anti-apoptotic actions in rat models of diabetes resulting in improved β-cell function and glycemic controlgip受体激动剂展品β-cell糖尿病模型大鼠抗凋亡的行为导致改善β-cell功能和血糖控制.pdfVIP

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a gip receptor agonist exhibits β-cell anti-apoptotic actions in rat models of diabetes resulting in improved β-cell function and glycemic controlgip受体激动剂展品β-cell糖尿病模型大鼠抗凋亡的行为导致改善β-cell功能和血糖控制.pdf

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a gip receptor agonist exhibits β-cell anti-apoptotic actions in rat models of diabetes resulting in improved β-cell function and glycemic controlgip受体激动剂展品β-cell糖尿病模型大鼠抗凋亡的行为导致改善β-cell功能和血糖控制

A GIP Receptor Agonist Exhibits b-Cell Anti-Apoptotic Actions in Rat Models of Diabetes Resulting in Improved b-Cell Function and Glycemic Control 1 1 1 1 1 1 Scott B. Widenmaier , Su-Jin Kim , Gary K. Yang , Thomas De Los Reyes , Cuilan Nian , Ali Asadi , 2 1 1 1 Yutaka Seino , Timothy J. Kieffer , Yin Nam Kwok , Christopher H. S. McIntosh * 1 Department of Cellular and Physiological Sciences and the Diabetes Research Group, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada, 2 Department of Diabetes and Clinical Nutrition, Kansai Electric Power Hospital, Osaka, Japan Abstract Aims: The gastrointestinal hormone GIP promotes pancreatic islet function and exerts pro-survival actions on cultured b-cells. However, GIP also promotes lipogenesis, thus potentially restricting its therapeutic use. The current studies evaluated the effects of a truncated GIP analog, D-Ala2-GIP1–30 (D-GIP1–30), on glucose homeostasis and b-cell mass in rat models of diabetes. Materials and Methods: The insulinotropic and pro-survival potency of D-GIP1–30 was evaluated in perfused pancreas preparations and cultured INS-1 b-cells, respectively, and receptor selectivity evaluated using wild type and GIP receptor knockout mice. Effects of D-GIP1–30 on b-cell function and glucose homeostasis, in vivo, were determined using Lean Zucker rats, obese Vancouver diabetic fatty rats, streptozotocin treated rats, and obese Zucker diabetic fatty rats, with effects on b- cell mass determined in histological studies of pancreatic tissue. Lipogenic effects of D-GIP1–30 were evaluated on cultu