a global analysis of tandem 3′utrs in eosinophilic chronic rhinosinusitis with nasal polyps全球分析串联3u2032utr嗜酸性慢性鼻窦炎鼻息肉.pdfVIP

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a global analysis of tandem 3′utrs in eosinophilic chronic rhinosinusitis with nasal polyps全球分析串联3u2032utr嗜酸性慢性鼻窦炎鼻息肉.pdf

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a global analysis of tandem 3′utrs in eosinophilic chronic rhinosinusitis with nasal polyps全球分析串联3u2032utr嗜酸性慢性鼻窦炎鼻息肉

A Global Analysis of Tandem 39UTRs in Eosinophilic Chronic Rhinosinusitis with Nasal Polyps 1. 2. 2. 1 2 2 1 2 2 Peng Tian , Yu Sun , Yuxin Li , Xiang Liu , Liang Wan , Jie Li , Yun Ma , Anlong Xu , Yonggui Fu *, Hua Zou1* 1 Department of Otorhinolaryngology-Head and Neck Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, P.R. China, 2 State Key Laboratory for Biocontrol, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, Department of Biochemistry, College of Life Sciences, Sun Yat-sen University, Higher Education Mega Center, Guangzhou, P.R. China Abstract Background: Alternative polyadenylation (APA) is emerging as a widespread mechanism of gene regulation. The usage of APA sites allows a single gene to encode multiple mRNA transcripts with different 39-untranslated region (39UTR) lengths. Many disease processes reflect the importance of the regulation of APA site switching. The objective of this study was to explore the profiling of tandem APA sites in nasal polyps compared with nasal uncinate process mucosa. Methods: Sequencing of APA sites (SAPAS) based on second-generation sequencing technology was undertaken to investigate the use of tandem APA sites and identify gene expression patterns in samples from the nasal polyps and nasal uncinate process mucosa of two patients with chronic rhinosinusitis with nasal polyps. The findings of the SAPAS analysis were validated via quantitative reverse-transcription polymerase chain reaction (qRT-PCR). Results: First, the results showed a switching of 39UTR lengths in nasal polyps compared with nasal uncinate process mucosa. From the two patients, 105 genes that were detected in b