a global overview of the genetic and functional diversity in the helicobacter pylori cag pathogenicity island全球概述遗传和功能多样性的幽门螺杆菌cag致病性岛.pdfVIP

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a global overview of the genetic and functional diversity in the helicobacter pylori cag pathogenicity island全球概述遗传和功能多样性的幽门螺杆菌cag致病性岛.pdf

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a global overview of the genetic and functional diversity in the helicobacter pylori cag pathogenicity island全球概述遗传和功能多样性的幽门螺杆菌cag致病性岛

A Global Overview of the Genetic and Functional Diversity in the Helicobacter pylori cag Pathogenicity Island 1.¤a 1. 2¤b 1 2 Patrick Olbermann , Christine Josenhans , Yoshan Moodley , Markus Uhr , Christiana Stamer , 3 1 2,4 2,5. Marc Vauterin , Sebastian Suerbaum *, Mark Achtman *, Bodo Linz 1 Institute for Medical Microbiology and Hospital Epidemiology, Medizinische Hochschule Hannover, Hannover, Germany, 2 Department of Molecular Biology, Max Planck Institute for Infection Biology, Berlin, Germany, 3 Applied Maths, Sint-Martens-Latem, Belgium, 4 Environmental Research Institute, University College Cork, Cork, Ireland, 5 Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania, United States of America Abstract The Helicobacter pylori cag pathogenicity island (cagPAI) encodes a type IV secretion system. Humans infected with cagPAI– carrying H. pylori are at increased risk for sequelae such as gastric cancer. Housekeeping genes in H. pylori show considerable genetic diversity; but the diversity of virulence factors such as the cagPAI, which transports the bacterial oncogene CagA into host cells, has not been systematically investigated. Here we compared the complete cagPAI sequences for 38 representative isolates from all known H. pylori biogeographic populations. Their gene content and gene order were highly conserved. The phylogeny of most cagPAI genes was similar to that of housekeeping genes, indicating that the cagPAI