- 1、本文档共6页,可阅读全部内容。
- 2、有哪些信誉好的足球投注网站(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。
- 3、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载。
- 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
- 5、该文档为VIP文档,如果想要下载,成为VIP会员后,下载免费。
- 6、成为VIP后,下载本文档将扣除1次下载权益。下载后,不支持退款、换文档。如有疑问请联系我们。
- 7、成为VIP后,您将拥有八大权益,权益包括:VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 8、VIP文档为合作方或网友上传,每下载1次, 网站将根据用户上传文档的质量评分、类型等,对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
a measles epidemic threshold in a highly vaccinated population麻疹流行阈值在一个高度人口接种疫苗
Open access, freely available online PLoS MEDICINE
A Measles Epidemic Threshold in a Highly
Vaccinated Population
*
Jacco Wallinga , Janneke C. M. Heijne, Mirjam Kretzschmar
Centre for Infectious Disease Epidemiology, National Institute for Public Health and the Environment, Bilthoven, the Netherlands
Competing Interests: The authors A B S T R A C T
have declared that no competing
interests exist. Background
Author Contributions: JW designed
the study. JW and JCMH collected Mass vaccination against measles has successfully lowered the incidence of the disease and
and analyzed the data. JW, JCMH, has changed the epidemic pattern from a roughly biennial cycle to an irregular sequence of
and MK contributed to writing the outbreaks. A possible explanation for this sequence of outbreaks is that the vaccinated
paper.
population is protected by solid herd immunity. If so, we would expect to see the fraction of
Academic Editor: Nigel Gay, Health susceptible individuals remaining below an epidemic threshold. An alternative explanation is
Protection Agency, United Kingdom the occurrence of occasional localised lapses in herd immunity that allow for major outbreaks
Citation: Wallinga J, Heijne JCM, in areas with a low vaccine coverage. In that case, we would expect the fraction of susceptible
Kretzschmar M (2005) A measles individuals to exceed an epidemic threshold before outbreaks occur. These two explanations
epidemic threshold in a highly
vaccinated population. PLoS Med for the irregular sequence of measles outbreaks can be tested against observations of both the
2(11): e316. fraction of susceptible individuals and infection attack rates.
Received: Ap
您可能关注的文档
- a comparison of donor-acceptor pairs for genetically encoded fret sensors application to the epac camp sensor as an example比较新的双基因编码的烦恼传感器应用epac阵营传感器作为一个例子.pdf
- a comparison of mathematical models for polarization of single eukaryotic cells in response to guided cues数学模型的比较单一的真核细胞的极化响应引导线索.pdf
- a comparison of parallel pyrosequencing and sanger clone-based sequencing and its impact on the characterization of the genetic diversity of hiv-1比较并行焦和桑格clone-based测序及其影响hiv - 1的基因多样性的特征.pdf
- a comparison of methods for classifying clinical samples based on proteomics data a case study for statistical and machine learning approaches比较临床样本分类方法基于蛋白质组学数据统计和机器学习方法的案例研究.pdf
- a comparative chemogenomics strategy to predict potential drug targets in the metazoan pathogen, schistosoma mansoni比较chemogenomics策略预测潜在的药物靶点在后生动物的病原体,曼氏裂体吸虫.pdf
- a comparison of phylogenetic network methods using computer simulation使用计算机模拟系统网络的比较方法.pdf
- a comparison of rpob and 16s rrna as markers in pyrosequencing studies of bacterial diversity比较rpob和16 s rrna焦磷酸测序研究的细菌多样性的标记.pdf
- a comparison of statistical methods for identifying out-of-date systematic reviews比较的统计方法确定过时的系统评价.pdf
- a comparison of mcc and cen error measures in multi-class prediction比较mcc和岑误差措施,多层次的预测.pdf
- a comparison of spatial and movement patterns between sympatric predators bull sharks (carcharhinus leucas) and atlantic tarpon (megalops atlanticus)同域的捕食者之间的空间和运动模式的比较牛鲨(carcharhinus莱夫卡斯岛)和大西洋大海鲢(megalops atlanticus).pdf
文档评论(0)