a meta-analysis of interleukin-10 -592 promoter polymorphism associated with gastric cancer risk白细胞介素- 10u201d-592的荟萃分析启动子多态性与胃癌相关的风险.pdfVIP

A Meta-Analysis of Interleukin-10 -592 Promoter Polymorphism Associated with Gastric Cancer Risk 1 . 1. 2. 3. 4. 4 1 Huiping Xue * , Ying-Chao Wang , Bing Lin , Jianfu An , Lu Chen , Jinxian Chen , Jing-Yuan Fang * 1 Division of Gastroenterology and Hepatology, Shanghai Jiao-Tong University School of Medicine Renji Hospital, Shanghai Institution of Digestive Disease and Key Laboratory of Gastroenterology Hepatology, Ministry of Health Shanghai Jiao-Tong University, Shanghai, People’s Republic of China, 2 Division of Nutrition, Zhongshan Hospital, Fudan University School of Medicine, Shanghai, People’s Republic of China, 3 Bioinformatics Department, Shanghai Jiaotong University School of Medicine, Shanghai, People’s Republic of China, 4 Department of General Surgery, Renji Hospital, Shanghai, People’s Republic of China Abstract We aimed to explore the role of IL-10 -592 A/C SNP in the susceptibility to gastric cancer through a systematic review and meta-analysis. Each initially included article was scored for quality appraisal. 17 studies were eligible for the meta-analysis. We adopted the most probably appropriate genetic model (recessive model). Potential sources of heterogeneity were sought out via subgroup and sensitivity analyses, and publication biases were estimated. IL-10-592 AA genotype is associated with the reduced risk of developing gastric cancer among Asians and even apparently observed among Asians high quality subgroup, suggesting IL-10-592 AA genotype may seem to be more protective from overall gastric cancer in Asian p