有哪些信誉好的足球投注网站a metasystem of framework model organisms to study emergence of new host-microbe adaptations框架模型的metasystem生物研究新宿主适应性的出现.pdfVIP
- 1、本文档共7页，可阅读全部内容。
- 2、有哪些信誉好的足球投注网站（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
- 3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 5、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 6、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 7、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 8、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
a metasystem of framework model organisms to study emergence of new host-microbe adaptations框架模型的metasystem生物研究新宿主适应性的出现
A Metasystem of Framework Model Organisms to Study
Emergence of New Host-Microbe Adaptations
Suresh Gopalan1,2*, Frederick M. Ausubel1,2
1 Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America, 2 Department of Genetics, Harvard Medical School,
Boston, Massachusetts, United States of America
Abstract
An unintended consequence of global industrialization and associated societal rearrangements is new interactions of
microbes and potential hosts (especially mammals and plants), providing an opportunity for the rapid emergence of host-
microbe adaptation and eventual establishment of new microbe-related diseases. We describe a new model system
comprising the model plant Arabidopsis thaliana and several microbes, each representing different modes of interaction, to
study such ‘‘maladaptations’’. The model microbes include human and agricultural pathogens and microbes that are
commonly considered innocuous. The system has a large knowledge base corresponding to each component organism and
is amenable to high-throughput automation assisted perturbation screens for identifying components that modulate host-
pathogen interactions. This would aid in the study of emergence and progression of host-microbe maladaptations in a
controlled environment.
Citation: Gopalan S, Ausubel FM (2008) A Metasystem of Framework Model Organisms to Study Emergence of New Host-Microbe Adaptations. PLoS ONE 3(12):
e3891. doi:10.1371/journal.pone.0003891
Editor: Niyaz Ahmed, Centre for DNA Fingerprinting and Diagnostics, India
Received November 7, 2008; Accepted November 13, 2008; Published December 10, 2008
Copyright: 2008 Gopalan et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits
您可能关注的文档
- a computational analysis of atp binding of sv40 large tumor antigen helicase motoratp结合的计算分析sv40大肿瘤抗原解旋酶马达.pdf
- a comprehensive overview of medical error in hospitals using incident-reporting systems, patient complaints and chart review of inpatient deaths一个全面的概述医疗错误使用事故报告系统在医院,病人住院病人死亡的投诉和图表回顾.pdf
- a computational analysis of limb and body dimensions in tyrannosaurus rex with implications for locomotion, ontogeny, and growth四肢和身体大小的计算分析霸王龙和对运动的影响,个体发生和发展.pdf
- a computational and experimental study of the regulatory mechanisms of the complement system计算和实验研究补体系统的监管机制.pdf
- a computational approach for deciphering the organization of glycosaminoglycans计算方法破译葡糖氨基葡聚糖的组织.pdf
- a computational approach to finding novel targets for existing drugs计算的方法为现有药物寻找新靶点.pdf
- a computational approach to analyze the mechanism of action of the kinase inhibitor bafetinib计算的方法分析了bafetinib激酶抑制剂的作用机制.pdf
- a computational approach to the functional screening of genomes计算基因组的功能筛选方法.pdf
- a computational approach to understand in vitro alveolar morphogenesis计算的方法了解体外肺泡形态发生.pdf
- a computational clonal analysis of the developing mouse limb bud计算克隆分析发展中鼠标肢芽.pdf
文档评论（0）