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a molecular model of blood cell renewal血液细胞的分子模型更新
Open access, freely available online
Research Digest
Synopses of Research Articles
Gene Targeting Turns Mice into Endurance training can enhance the and decreased level of specialized type
Long-Distance Runners metabolic performance of muscle types, II contractile proteins in the transgenic
and now it appears that training can also mice. Interestingly, these same results
DOI: 10.1371/journal.pbio.0020322
induce conversion between fi ber types. were seen when naturally occurring
Specifi c changes in gene expression (endogenous) PPARδ levels were
Have you ever noticed that long-
trigger this oxidative fi ber transformation, stimulated in the normal mice (with
distance runners and sprinters seem
an orally active compound).
specially engineered for their
This suggests that muscle fi bers
sports? One’s built for distance,
can be transformed into type
the other speed. The ability to
I endurance fi bers by simply
generate quick bursts of power or
activating the endogenou
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