a multi-center study to evaluate the performance of phage amplified biologically assay for detecting tb in sputum in the pulmonary tb patients一项多中心研究来评估性能的噬菌体生物放大试验检测结核病在肺结核病人的痰.pdfVIP

下载本文档

0
0
约4.01万字
约 6页
2017-09-04 发布于上海
举报
版权申诉

a multi-center study to evaluate the performance of phage amplified biologically assay for detecting tb in sputum in the pulmonary tb patients一项多中心研究来评估性能的噬菌体生物放大试验检测结核病在肺结核病人的痰.pdf

1、本文档共6页，可阅读全部内容。
2、有哪些信誉好的足球投注网站（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
5、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
6、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
7、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
8、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

a multi-center study to evaluate the performance of phage amplified biologically assay for detecting tb in sputum in the pulmonary tb patients一项多中心研究来评估性能的噬菌体生物放大试验检测结核病在肺结核病人的痰

A Multi-Center Study to Evaluate the Performance of Phage Amplified Biologically Assay for Detecting TB in Sputum in the Pulmonary TB Patients 1,2 1 1 1 1 1 1 Changtai Zhu , Zhenling Cui , Ruijuan Zheng , Hua Yang , Ruiliang Jin , Lianhua Qin , Zhonghua Liu , 1 1 Jie Wang , Zhongyi Hu * 1 Shanghai Key Laboratory of Tuberculosis, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, People’s Republic of China, 2 Department of Laboratory Medicine, Changzhou Tumor Hospital Soochow University, Changzhou, People’s Republic of China Abstract Objective: To evaluate the performance of phage amplified biologically assay (PhaB) for detecting tuberculosis (TB) in sputum in the pulmonary tuberculosis (PTB) patients. Methods: Shanghai Tuberculosis Key Laboratory of Shanghai Pulmonary Hospital participated in the project in collaboration with the laboratories of six hospitals and a total of 1660 eligible participants (1351 PTB patients and 309 non-TB patients) were included in the study. The sputum samples from the participants were detected by smear microscopy, PhaB, and ¨ Lowenstein-Jensen (L-J) culture method, respectively. Results: The overall sensitivity of PhaB were higher than that of L-J culture and smear microscopy (p ,0.05). The sensitivity of PhaB for detecting smear-negative specimens was obviously higher than that of L-J culture (p ,0.05). Compared with L-J culture, the overall sensitivity, specificity, PPV, NPV, ACC and Kappa value of PhaB were 98.4 (95% Cl: 96.9–99.3), 71.6 (95% Cl: 68.4–74.6), 67.7, 98.7, 81.7% and 0.643, respectively. The detection median time of PhaB only needed 48 hours, which was significantly less than