a multi-compartment model for interneurons in the dorsal lateral geniculate nucleus中间神经元的多级模型在背外侧膝状体核.pdfVIP
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a multi-compartment model for interneurons in the dorsal lateral geniculate nucleus中间神经元的多级模型在背外侧膝状体核
A Multi-Compartment Model for Interneurons in the
Dorsal Lateral Geniculate Nucleus
1 2 2 1 3
Geir Halnes *, Sigita Augustinaite , Paul Heggelund , Gaute T. Einevoll , Michele Migliore
˚
1 IMT, Norwegian University of Life Sciences, As, Norway, 2 Department of Physiology, University of Oslo, Oslo, Norway, 3 Institute of Biophysics, National Research
Council, Palermo, Italy
Abstract
GABAergic interneurons (INs) in the dorsal lateral geniculate nucleus (dLGN) shape the information flow from retina to
cortex, presumably by controlling the number of visually evoked spikes in geniculate thalamocortical (TC) neurons, and
refining their receptive field. The INs exhibit a rich variety of firing patterns: Depolarizing current injections to the soma may
induce tonic firing, periodic bursting or an initial burst followed by tonic spiking, sometimes with prominent spike-time
adaptation. When released from hyperpolarization, some INs elicit rebound bursts, while others return more passively to the
resting potential. A full mechanistic understanding that explains the function of the dLGN on the basis of neuronal
morphology, physiology and circuitry is currently lacking. One way to approach such an understanding is by developing a
detailed mathematical model of the involved cells and their interactions. Limitations of the previous models for the INs of
the dLGN region prevent an accurate representation of the conceptual framework needed to understand the computational
properties of this region. We here present a detailed compartmental model of INs using, for the first time, a morphological
reconstruction and a set of active dendritic conductances constrai
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