a multifaceted analysis of immune-endocrine-metabolic alterations in patients with pulmonary tuberculosis多方面的分析immune-endocrine-metabolic改变肺结核患者.pdfVIP

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a multifaceted analysis of immune-endocrine-metabolic alterations in patients with pulmonary tuberculosis多方面的分析immune-endocrine-metabolic改变肺结核患者.pdf

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a multifaceted analysis of immune-endocrine-metabolic alterations in patients with pulmonary tuberculosis多方面的分析immune-endocrine-metabolic改变肺结核患者

A Multifaceted Analysis of Immune-Endocrine-Metabolic Alterations in Patients with Pulmonary Tuberculosis 1 1 2 ´ 1 3 Natalia Santucci , Luciano D’Attilio , Leandro Kovalevski , Veronica Bozza , Hugo Besedovsky , 3 ´ 1 1 Adriana del Rey , Marıa Luisa Bay , Oscar Bottasso * ´ ´ ´ 1 Instituto de Inmunologıa, Facultad de Ciencias Medicas, Universidad Nacional de Rosario, Rosario, Argentina, 2 Instituto de Investigaciones Teoricas y Aplicadas, Escuela ´ ´ ´ de Estadıstica, Facultad de Ciencias Economicas y Estadıstica, Universidad Nacional de Rosario, Rosario, Argentina, 3 Institute of Physiology and Pathophysiology, Marburg, Germany Abstract Our study investigated the circulating levels of factors involved in immune-inflammatory-endocrine-metabolic responses in patients with tuberculosis with the aim of uncovering a relation between certain immune and hormonal patterns, their clinical status and in vitro immune response. The concentration of leptin, adiponectin, IL-6, IL-1b, ghrelin, C-reactive protein (CRP), cortisol and dehydroepiandrosterone (DHEA), and the in vitro immune response (lymphoproliferation and IFN-c production) was evaluated in 53 patients with active untreated tuberculosis, 27 household contacts and 25 healthy controls, without significant age- or sex-related differences. Patients had a lower body mass index (BMI), reduced levels of leptin and DHEA, and increa