a nationwide survey of the quality of antimalarials in retail outlets in tanzania一项全国性的调查质量的抗疟药在坦桑尼亚的零售网点.pdfVIP

A Nationwide Survey of the Quality of Antimalarials in Retail Outlets in Tanzania 1 2 4 5 6 Harparkash Kaur *, Catherine Goodman *, Eloise Thompson , Katy-Anne Thompson , Irene Masanja , S. Patrick Kachur7, Salim Abdulla6 1 Clinical Research Unit, London School of Hygiene Tropical Medicine, London, United Kingdom, 2 Health Policy Unit, London School of Hygiene Tropical Medicine, London, United Kingdom, 3 KEMRI/Wellcome Trust Research Programme, Nairobi, Kenya, 4 Immunology Unit, London School of Hygiene Tropical Medicine, London, United Kingdom, 5 London School of Hygiene Tropical Medicine, London, United Kingdom, 6 Ifakara Health Research and Development Centre, Dar es Salaam, Tanzania, 7 Malaria Branch, US Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America Abstract Introduction: Retail pharmaceutical products are commonly used to treat fever and malaria in sub-Saharan African countries. Small scale studies have suggested that poor quality antimalarials are widespread throughout the region, but nationwide data are not available that could lead to generalizable conclusions about the extent to which poor quality drugs are available in African communities. This study aimed to assess the quality of antimalarials available from retail outlets across mainland Tanzania. Methods and Findings: We systematically purchased samples of oral antimalarial tablets from retail outlets across 21 districts in mainland Tanzania in 2005. A total of 1080 antimalarial formulations were collected including 679 antifol antimalarial samples (394 sulfadoxine/pyrimethamine and 285 sulfamethoxypyrazine/pyrimethamine), 260 amodiaquine samples