a new mixed-backbone oligonucleotide against glucosylceramide synthase sensitizes multidrug-resistant tumors to apoptosis一个新的mixed-backbone寡核苷酸对葡糖神经酰胺合成酶糖分会让耐多药肿瘤细胞凋亡.pdfVIP

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a new mixed-backbone oligonucleotide against glucosylceramide synthase sensitizes multidrug-resistant tumors to apoptosis一个新的mixed-backbone寡核苷酸对葡糖神经酰胺合成酶糖分会让耐多药肿瘤细胞凋亡.pdf

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a new mixed-backbone oligonucleotide against glucosylceramide synthase sensitizes multidrug-resistant tumors to apoptosis一个新的mixed-backbone寡核苷酸对葡糖神经酰胺合成酶糖分会让耐多药肿瘤细胞凋亡

A New Mixed-Backbone Oligonucleotide against Glucosylceramide Synthase Sensitizes Multidrug-Resistant Tumors to Apoptosis 1 2 1,7 1 3 4 Gauri A. Patwardhan , Qian-Jin Zhang , Dongmei Yin , Vineet Gupta , Jianxiong Bao , Can E. Senkal , 4 5 1 1 6 Besim Ogretmen , Myles C. Cabot , Girish V. Shah , Paul W. Sylvester , S. Michal Jazwinski , Yong-Yu Liu1* 1 Department of Basic Pharmaceutical Sciences, University of Louisiana at Monroe, Monroe, Louisiana, United States of America, 2 Department of Cellular Biology and Anatomy, Louisiana State University Health Sciences Center, Shreveport, Louisiana, United States of America, 3 Department of Pathology, Louisiana State University Health Sciences Center, Shreveport, Louisiana, United States of America, 4 Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina, United States of America, 5 Experimental Therapeutics, John Wayne Cancer Institute, Santa Monica, California, United States of America, 6 Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana, United States of America, 7 Department of Biochemistry, Nantong University School of Medicine, Nantong, Jiangsu, China Abstract Enhanced ceramide glycosylation catalyzed by glucosylceramide synthase (GCS) limits therapeutic efficiencies of antineoplastic agents including doxorubicin in drug-resistant cancer cells. Aimed to determine the role of GCS in tumor response to chemotherapy, a new mixed-backbone oligonucleotide (MBO-asGCS) with higher stability and efficiency has been generat