a new integrated variable based on thermometry, actimetry and body position (tap) to evaluate circadian system status in humans一个新的综合变量基于温度测量,actimetry和身体位置(tap)对人类生理系统状态进行评估.pdfVIP

A New Integrated Variable Based on Thermometry, Actimetry and Body Position (TAP) to Evaluate Circadian System Status in Humans 1 1 2 ´ ´ 1 Elisabet Ortiz-Tudela , Antonio Martinez-Nicolas , Manuel Campos , Marıa Angeles Rol *, Juan Antonio Madrid1 1 Chronobiology Laboratory, Department of Physiology, University of Murcia, Murcia, Spain, 2 Department of Computer Science and Systems, University of Murcia, Murcia, Spain Abstract The disruption of the circadian system in humans has been associated with the development of chronic illnesses and the worsening of pre-existing pathologies. Therefore, the assessment of human circadian system function under free living conditions using non-invasive techniques needs further research. Traditionally, overt rhythms such as activity and body temperature have been analyzed separately; however, a comprehensive index could reduce individual recording artifacts. Thus, a new variable (TAP), based on the integrated analysis of three simultaneous recordings: skin wrist temperature (T), motor activity (A) and body position (P) has been developed. Furthermore, we also tested the reliability of a single numerical index, the Circadian Function Index (CFI), to determine the circadian robustness. An actimeter and a temperature sensor were placed on the arm and wrist of the non-dominant hand, respectively, of 49 healthy young volunteers for a period of one week. T, A and P values were normalized for each subject. A non-parametric analysis was applied to both TAP and the separate variables to calculate their interdaily stability, intradaily variability and relative amplitude, and these values were then used for the CFI calculation. Modeling analyses were performed in order to determine TAP