a new module in neural differentiation control two micrornas upregulated by retinoic acid, mir-9 and -103, target the differentiation inhibitor id2新模块在神经分化控制两个microrna调节由视黄酸,分化抑制剂id2 mir-9和-103年目标.pdfVIP

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a new module in neural differentiation control two micrornas upregulated by retinoic acid, mir-9 and -103, target the differentiation inhibitor id2新模块在神经分化控制两个microrna调节由视黄酸,分化抑制剂id2 mir-9和-103年目标.pdf

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a new module in neural differentiation control two micrornas upregulated by retinoic acid, mir-9 and -103, target the differentiation inhibitor id2新模块在神经分化控制两个microrna调节由视黄酸,分化抑制剂id2 mir-9和-103年目标

A New Module in Neural Differentiation Control: Two MicroRNAs Upregulated by Retinoic Acid, miR-9 and -103, Target the Differentiation Inhibitor ID2 1.¤a 2. 1 1¤b 1,3 1,2 Daniela Annibali , Ubaldo Gioia , Mauro Savino , Pietro Laneve , Elisa Caffarelli *, Sergio Nasi * ` 1 Consiglio Nazionale delle Ricerche - Istituto di Biologia e Patologia Molecolari (CNR – IBPM), Dipartimento di Biologia e Biotecnologie, Universita Sapienza, Roma, Italia, ` ` 2 Dipartimento di Biologia e Biotecnologie, Universita Sapienza, Roma, Italia, 3 Center for Life Nano Science @Sapienza, Istituto Italiano di Tecnologia, Universita Sapienza, Roma, Italia Abstract The transcription factor ID2 is an important repressor of neural differentiation strongly implicated in nervous system cancers. MicroRNAs (miRNAs) are increasingly involved in differentiation control and cancer development. Here we show that two miRNAs upregulated on differentiation of neuroblastoma cells – miR-9 and miR-103 – restrain ID2 expression by directly targeting the coding sequence and 39 untranslated region of the ID2 encoding messenger RNA, respectively. Notably, the two miRNAs show an inverse correlation with ID2 during neuroblastoma cell differentiation induced by retinoic acid. Overexpression of miR-9 and miR-103 in neuroblastoma cells reduces proliferation and promotes differentiation, as it