有哪些信誉好的足球投注网站a new role for translation initiation factor 2 in maintaining genome integrity一个新的角色翻译起始因子2在维持基因组的完整性.pdfVIP
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a new role for translation initiation factor 2 in maintaining genome integrity一个新的角色翻译起始因子2在维持基因组的完整性
A New Role for Translation Initiation Factor 2 in
Maintaining Genome Integrity
K. Elizabeth Madison, Mona R. Abdelmeguid, Erica N. Jones-Foster, Hiroshi Nakai*
Department of Biochemistry and Molecular and Cellular Biology, Georgetown University Medical Center, Washington, D.C, United States of America
Abstract
Escherichia coli translation initiation factor 2 (IF2) performs the unexpected function of promoting transition from
recombination to replication during bacteriophage Mu transposition in vitro, leading to initiation by replication restart
proteins. This function has suggested a role of IF2 in engaging cellular restart mechanisms and regulating the maintenance
of genome integrity. To examine the potential effect of IF2 on restart mechanisms, we characterized its influence on cellular
recovery following DNA damage by methyl methanesulfonate (MMS) and UV damage. Mutations that prevent expression of
full-length IF2-1 or truncated IF2-2 and IF2-3 isoforms affected cellular growth or recovery following DNA damage
differently, influencing different restart mechanisms. A deletion mutant (del1) expressing only IF2-2/3 was severely sensitive
to growth in the presence of DNA-damaging agent MMS. Proficient as wild type in repairing DNA lesions and promoting
replication restart upon removal of MMS, this mutant was nevertheless unable to sustain cell growth in the presence of
MMS; however, growth in MMS could be partly restored by disruption of sulA, which encodes a cell division inhibitor
induced during replication fork arrest. Moreover, such characteristics of del1 MMS sensitivity were shared by restart mutant
priA300, which encodes a helicase-deficient restart protein. Epistasis analysis indicated that del1 in combination with priA300
had no further effects on cellular recovery
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