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a new tile in the biochemical puzzle of insulin biology新瓷砖生化胰岛素生物学难题
Synopses of Research Articles
Looping Out Introns to Help Splicing
Richard Robinson | DOI: 10.1371/journal.pbio.0040041
One of the most surprising discoveries help the splicing machinery remove
in molecular biology was that a gene’s the intron. The authors further
coding region is broken up into smaller support their model by showing that
pieces (the exons) interrupted by splicing could also be stimulated just
noncoding portions called introns. by inserting complementary RNA
After the DNA is transcribed into RNA, sequences at each end of the intron.
and before the RNA can leave the These have the ability to bind to one
nucleus, the introns must be cut out another, forming the intron into a
and the exons spliced together. DOI: 10.1371/journal.pbio.0040041.g001 loop.
Since introns were discovered However, they note that in some
Two hnRNP proteins interact to connect
in 1977, the details of the splicing introns, only one hnRNP A/B site,
the two ends of an intron, forming a loop to
operations have been a major object help the cell’s splicing machinery remove positioned on the upstream end, is
of study. For sp
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