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a new strategy to identify and annotate human rpe-specific gene expression一个新的策略来识别和注释人类rpe-specific基因表达
A New Strategy to Identify and Annotate Human
RPE-Specific Gene Expression
1 1 2,3 2
Judith C. Booij , Jacoline B. ten Brink , Sigrid M. A. Swagemakers , Annemieke J. M. H. Verkerk ,
1 2 1,4,5
Anke H. W. Essing , Peter J. van der Spek , Arthur A. B. Bergen *
1 Department of Clinical and Molecular Ophthalmogenetics, Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Amsterdam, The
Netherlands, 2 Department of Bioinformatics and Genetics, Erasmus Medical Center, Rotterdam, The Netherlands, 3 Cancer Genomics Centre, Erasmus Medical Center,
Rotterdam, The Netherlands, 4 Clinical Genetics Academic Medical Centre Amsterdam, University of Amsterdam, The Netherlands, 5 Department of Ophthalmology,
Academic Medical Centre Amsterdam, University of Amsterdam, The Netherlands
Abstract
Background: To identify and functionally annotate cell type-specific gene expression in the human retinal pigment
epithelium (RPE), a key tissue involved in age-related macular degeneration and retinitis pigmentosa.
Methodology: RPE, photoreceptor and choroidal cells were isolated from selected freshly frozen healthy human donor eyes
using laser microdissection. RNA isolation, amplification and hybridization to 44 k microarrays was carried out according to
Agilent specifications. Bioinformatics was carried out using Rosetta Resolver, David and Ingenuity software.
Principal Findings: Our previous 22 k analysis of the RPE transcriptome showed that the RPE has high levels of protein
synthesis, strong energy demands, is exposed to hi
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