a population-based study of gastroesophageal reflux disease and sleep problems in elderly twins以人群为基础的研究老年胃食管返流疾病和睡眠问题的双胞胎.pdfVIP

A Population-Based Study of Gastroesophageal Reflux Disease and Sleep Problems in Elderly Twins 1 2 1 3 1,4 Anna Lindam *, Catarina Jansson , Helena Nordenstedt , Nancy L. Pedersen , Jesper Lagergren 1 Unit of Upper Gastrointestinal Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden, 2 Division of Insurance Medicine, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden, 3 Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden, 4 Division of Cancer Studies, Kings College London, London, United Kingdom Abstract Background Aims: Previous studies indicate an association between sleep problems and gastroesophageal reflux disease (GERD). Although both these conditions separately have moderate heritabilities, confounding by genetic factors has not previously been taken into account. This study aimed to reveal the association between sleep problems and GERD, while adjusting for heredity and other potential confounding factors. Methods: This cross-sectional population-based study included all 8,014 same-sexed twins of at least 65 years of age and born in Sweden between 1886 and 1958, who participated in telephone interviews in 1998–2002. Three logistic regression models were used 1) external control analysis, 2) within-pair co-twin analysis with dizygotic (DZ) twin pairs discordant for GERD, and 3) within-pair co-twin analysis with monozygotic (MZ) twin pairs discordant for GERD. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated and adjusted for established risk factors for GERD, i.e. sex, age, body mass index (BMI), tobacco smoking, and educational level. Results: A dose-response association was identified between increas