a plant-derived remedy for repair of infarcted heart基于植物的治疗修复梗塞的心.pdfVIP

A Plant-Derived Remedy for Repair of Infarcted Heart 1,2 1,2 5 4 6 2 3 Lei Cheng , Hao Chen , Xinsheng Yao , Guoqing Qi , Hongwei Liu , Kwongman Lee , Kaho Lee , 1,2 1,2 1 1 1 1,2 Jieting Zhang , Shihui Chen , Xiaoli Lin , Wenchao Zhao , Jiankuan Li , Ming Li * 1 Key Laboratory for Regenerative Medicine of Ministry of Education of China, The Chinese University of Hong Kong, Hong Kong SAR, China, 2 Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China, 3 Department of Anatomy, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China, 4 Department of Cardiology, The First Affiliated Hospital, Hebei Medical University, Shijiazhuang, China, 5 Department of Pharmacology, Jian University, Guangzhou, China, 6 Key Laboratory of Systematic Mycology and Lichenology, Institute of Microbiology, Chinese Academy of Sciences, Chaoyang District, Beijing, China Abstract Background: Myocardial infarction (MI) due to coronary artery disease remains one of the leading causes of premature death. Replacement of infarcted heart tissue with regenerating myocardium from endogenous progenitor pools or exogenously introduced stem cells remains a therapeutic ideal. Their impracticality mainly lies in their low efficiency in cardiogenic differentiation (CD). Our recent studies with an acute MI animal model have already demonstrated the therapeutic effect of the MeOH extract of Geum japonicum (EGJ), providing clear e