a positive feedback loop links opposing functions of p-tefbcdk9 and histone h2b ubiquitylation to regulate transcript elongation in fission yeast积极的反馈回路链接反对p-tefbcdk9功能和组蛋白h2b ubiquitylation调节转录延伸裂殖酵母.pdfVIP

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a positive feedback loop links opposing functions of p-tefbcdk9 and histone h2b ubiquitylation to regulate transcript elongation in fission yeast积极的反馈回路链接反对p-tefbcdk9功能和组蛋白h2b ubiquitylation调节转录延伸裂殖酵母.pdf

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a positive feedback loop links opposing functions of p-tefbcdk9 and histone h2b ubiquitylation to regulate transcript elongation in fission yeast积极的反馈回路链接反对p-tefbcdk9功能和组蛋白h2b ubiquitylation调节转录延伸裂殖酵母

A Positive Feedback Loop Links Opposing Functions of P-TEFb/Cdk9 and Histone H2B Ubiquitylation to Regulate Transcript Elongation in Fission Yeast ´ 1. 1. 1. ´ 2 ´ 3 Miriam Sanso , Karen M. Lee , Laia Viladevall , Pierre-Etienne Jacques , Viviane Page , 3 3 4 5 5 6 Stephen Nagy , Ariane Racine , Courtney V. St. Amour , Chao Zhang , Kevan M. Shokat , Beate Schwer , 2 1 3 Franc¸ois Robert , Robert P. Fisher *, Jason C. Tanny * 1 Department of Structural and Chemical Biology, Mount Sinai School of Medicine, New York, New York, United States of America, 2 Institut de Recherches Cliniques de ´ ´ ´ Montreal, Montreal, Canada, 3 Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada, 4 Programs in Biochemistry, Cell and Molecular Biology, Weill Cornell Medical College, New York, New York, United States of America, 5 Howard Hughes Medical Institute and Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, California, United States of America, 6 Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, United States of America Abstract Transcript elongation by RNA polymerase II (RNAPII) is accompanied by conserved patterns of histone modification. Whereas histone modifications have established roles in transcription initiation, their functions during elongation ar