a preclinical evaluation of alternative synthetic biomaterials for fascial defect repair using a rat abdominal hernia model筋膜缺损的临床前评价的替代合成生物材料修复使用老鼠腹部疝模型.pdfVIP

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a preclinical evaluation of alternative synthetic biomaterials for fascial defect repair using a rat abdominal hernia model筋膜缺损的临床前评价的替代合成生物材料修复使用老鼠腹部疝模型.pdf

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a preclinical evaluation of alternative synthetic biomaterials for fascial defect repair using a rat abdominal hernia model筋膜缺损的临床前评价的替代合成生物材料修复使用老鼠腹部疝模型

A Preclinical Evaluation of Alternative Synthetic Biomaterials for Fascial Defect Repair Using a Rat Abdominal Hernia Model 1,2,4 3 3 1 3 Daniela Ulrich , Sharon L. Edwards , Jacinta F. White , Tommy Supit , John A. M. Ramshaw , 1 4 3 1,4 Camden Lo , Anna Rosamilia , Jerome A. Werkmeister , Caroline E. Gargett * 1 Monash Institute of Medical Research, Clayton, Victoria, Australia, 2 Medical University Graz, Graz, Austria, 3 CSIRO Materials Science and Engineering, Clayton, Victoria, Australia, 4 Department of Obstetrics and Gynaecology and Monash Micro Imaging, Monash Medical Centre, Monash University, Clayton, Victoria, Australia Abstract Introduction: Fascial defects are a common problem in the abdominal wall and in the vagina leading to hernia or pelvic organ prolapse that requires mesh enhancement to reduce operation failure. However, the long-term outcome of synthetic mesh surgery may be unsatisfactory due to post-surgical complications. We hypothesized that mesh fabricated from alternative synthetic polymers may evoke a different tissue response, and provide more appropriate mechanical properties for hernia repair. Our aim was to compare the in vivo biocompatibility of new synthetic meshes with a commercial mesh. Methods: We have fabricated 3 new warp-knitted synthetic meshes from different polymers with different tensile properties polyetheretherketone (PEEK), polyamide (PA) and a composite, gelatin coated PA (PA+G). The rat abdominal hernia model was used to implant the meshes (25 635 mm, n = 24/ group). After 7, 30, 60, 90 days tissues were