a proposed classification of the immunological diseases提出了分类的免疫性疾病.pdfVIP

Research in Translation A Proposed Classifi cation of the Immunological Diseases * Dennis McGonagle , Michael F. McDermott century ago Paul Ehrlich Box 1. Defi nitions of from genetic and molecular studies proposed that immune Autoimmunity and and improved clinical insights into Areactivity against self, which he Autoinfl ammation disease in order to propose a unifi ed called “horror autotoxicus” and which classifi cation and theoretical framework is now called autoimmunity, would Generic Defi nition of Autoimmunity for all immunological diseases. be incompatible with life because of Self-directed infl ammation, whereby potentially devastating consequences aberrant dendritic cell, B and T cell, Key Studies That Defi ned for the host. But Ehrlich was proven responses in primary and secondary Autoinfl ammation as the Opposite wrong after the demonstration of lymphoid organs lead to breaking of of Autoimmunity autoantibodies and the emergence of a tolerance, with development of immune The recent elucidation of mechanisms theoretical basis for autoreactivity [1]. reactivity towards native antigens. The underlying self-directed tissue Conceptually, autoimmunity is viewed adaptive immune response plays the infl ammation independent of B or T as a defect of either B or T lymphocyte predominant role in the eventual clinical cell abnormalities could