a quantitative model of human jejunal smooth muscle cell electrophysiology人类空肠平滑肌细胞电生理学的定量模型.pdfVIP

A Quantitative Model of Human Jejunal Smooth Muscle Cell Electrophysiology 1,2 1 1 1,2 Yong Cheng Poh , Alberto Corrias , Nicholas Cheng , Martin Lindsay Buist * 1 Department of Bioengineering, National University of Singapore, Singapore, Singapore, 2 NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Centre for Life Sciences (CeLS), Singapore, Singapore Abstract Recently, a number of ion channel mutations have been identified in the smooth muscle cells of the human jejunum. Although these are potentially significant in understanding diseases that are currently of unknown etiology, no suitable computational cell model exists to evaluate the effects of such mutations. Here, therefore, a biophysically based single cell model of human jejunal smooth muscle electrophysiology is presented. The resulting cellular description is able to reproduce experimentally recorded slow wave activity and produces realistic responses to a number of perturbations, providing a solid platform on which the causes of intestinal myopathies can be investigated. Citation: Poh YC, Corrias A, Cheng N, Buist ML (2012) A Quantitative Model of Human Jejunal Smooth Muscle Cell Electrophysiology. PLoS ONE 7(8): e42385. doi:10.1371/journal.pone.0042385 Editor: Christof Markus Aegerter, University of Zurich, Switzerland Received April 10, 2012; Accepted July 4, 2012; Published August 17, 2012 Copyright: 2012 Poh et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source a