a quorum-sensing factor in vegetative dictyostelium discoideum cells revealed by quantitative migration analysis营养盘基网柄菌的群体感应因素discoideum定量迁移分析揭示了细胞.pdfVIP
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a quorum-sensing factor in vegetative dictyostelium discoideum cells revealed by quantitative migration analysis营养盘基网柄菌的群体感应因素discoideum定量迁移分析揭示了细胞
A Quorum-Sensing Factor in Vegetative Dictyostelium
Discoideum Cells Revealed by Quantitative Migration
Analysis
´ 1 ` 1 2 1
Laurent Gole , Charlotte Riviere , Yoshinori Hayakawa , Jean-Paul Rieu *
` ´ ´ ´
1 Laboratoire de Physique de la Matiere Condensee et Nanostructures, Universite de Lyon, Universite de Lyon I, CNRS, UMR 5586, Villeurbanne, France, 2 Center for
Information Technology in Education, Tohoku University, Sendai, Japan
Abstract
Background: Many cells communicate through the production of diffusible signaling molecules that accumulate and once a
critical concentration has been reached, can activate or repress a number of target genes in a process termed quorum
sensing (QS). In the social amoeba Dictyostelium discoideum, QS plays an important role during development. However little
is known about its effect on cell migration especially in the growth phase.
Methods and Findings: To investigate the role of cell density on cell migration in the growth phase, we use multisite
timelapse microscopy and automated cell tracking. This analysis reveals a high heterogeneity within a given cell population,
and the necessity to use large data sets to draw reliable conclusions on cell motion. In average, motion is persistent for short
periods of time (t ƒ5min), but normal diffusive behavior is recovered over longer time periods. The persistence times are
positively correlated with the migrated distances. Interestingly, the migrated distance decreases as well with cell density.
The adaptation of cell migration to cell density highlights the role of a secreted quorum sensing factor (QSF) on cell
migrat
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