a replication study of the association between rheumatoid arthritis and deletion of the late cornified envelope genes lce3b and lce3c一个复制的研究之间的联系类风湿性关节炎和删除基因lce3b和lce3c cornified末的信封.pdfVIP

A Replication Study of the Association between Rheumatoid Arthritis and Deletion of the Late Cornified Envelope Genes LCE3B and LCE3C 1 ˇ ´ ´ 2 3 4 2 Judith G. M. Bergboer , Masa Umicevic-Mirkov , Jaap Fransen , Martin den Heijer , Barbara Franke , 3 1 2 Piet L. C. M. van Riel , Joost Schalkwijk , Marieke J. H. Coenen *, on behalf of the Nijmegen Biomedical Study principal investigators 1 Department of Dermatology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands, 2 Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands, 3 Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands, 4 Department of Endocrinology and Department of Epidemiology and Biostatistics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands Abstract Objective: Two recent studies, in a Spanish and a Chinese population, point to an association between rheumatoid arthritis (RA) risk and the deletion of the Late Cornified Envelope (LCE) 3B and 3C genes (LCE3C_LCE3B-del), a known risk factor for psoriasis. We aimed to replicate these studies in a large Dutch cohort. Methods: 1039 RA cases and 759 controls were genotyped for LCE3C_LCE3B-del. Association analysis was performed for the complete cohort and after stratification for the serologic markers anti-cyclic citrullinated peptide and rheumatoid factor. A meta-analysis was performed combining our data with the Spanish and Chinese datasets, resulting in an analysis including 2466 RA cases and 2438 controls. Results: In the Dutch cohort we did not observe a sign