a research agenda for malaria eradication basic science and enabling technologies根除疟疾的研究议程基础科学和可行的技术.pdfVIP
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a research agenda for malaria eradication basic science and enabling technologies根除疟疾的研究议程基础科学和可行的技术
Review
A Research Agenda for Malaria Eradication: Basic Science
and Enabling Technologies
The malERA Consultative Group on Basic Science and Enabling Technologies *
use in the field of malaria eradication. From these new avenues of
Abstract: Today’s malaria control efforts are limited by investigation, it is reasonable to expect advances in vaccine
our incomplete understanding of the biology of Plasmo- development and the identification of novel drug targets.
dium and of the complex relationships between human Moreover, the interlacing of high-throughput molecular technol-
populations and the multiple species of mosquito and ogies with population studies will greatly facilitate the rational
parasite. Research priorities include the development of in
application of interventions in diverse malaria-endemic environ-
vitro culture systems for the complete life cycle of P.
ments and, we anticipate, will significantly increase our ability to
falciparum and P. vivax and the development of an
shed light on complex and heterogeneous host-parasite-vector
appropriate liver culture system to study hepatic stages.
interactions.
In addition, genetic technologies for the manipula
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