a research agenda for malaria eradication diagnoses and diagnostics根除疟疾诊断和诊断的研究议程.pdfVIP

Review A Research Agenda for Malaria Eradication: Diagnoses and Diagnostics The malERA Consultative Group on Diagnoses and Diagnostics * individuals (and, in the case of P. vivax, in the blood of Abstract: Many of malaria’s signs and symptoms are symptomatic individuals) who may contribute to continuing indistinguishable from those of other febrile diseases. malaria transmission [15–21] will become essential. Furthermore, Detection of the presence of Plasmodium parasites is novel strategies will be needed to incorporate these new and essential, therefore, to guide case management. Improved improved diagnostics into routine health service activities. diagnostic tools are required to enable targeted treat- More specifically, to avoid onward transmission, elimination ment of infected individuals. In addition, field-ready programs for malaria will increasingly need to focus on detecting the diagnostic tools for mass screening and surveillance that highest possible fraction of infections in the general population can detect asymptomatic infections of very low parasite densities are needed to monitor transmission reduction through active rather than passive case detection. This change of and ensure elimination. Antibody-based tests for infection