a retrospective analysis of the haemodynamic and metabolic effects of fluid resuscitation in vietnamese adults with severe falciparum malaria回顾性分析液体复苏在越南的血流动力学和代谢影响成人严重的恶性疟疾.pdfVIP

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a retrospective analysis of the haemodynamic and metabolic effects of fluid resuscitation in vietnamese adults with severe falciparum malaria回顾性分析液体复苏在越南的血流动力学和代谢影响成人严重的恶性疟疾.pdf

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a retrospective analysis of the haemodynamic and metabolic effects of fluid resuscitation in vietnamese adults with severe falciparum malaria回顾性分析液体复苏在越南的血流动力学和代谢影响成人严重的恶性疟疾

A Retrospective Analysis of the Haemodynamic and Metabolic Effects of Fluid Resuscitation in Vietnamese Adults with Severe Falciparum Malaria 1. 2 . 3 1 1 Nguyen Hoan Phu *, Josh Hanson * , Delia Bethell , Nguyen Thi Hoang Mai , Tran Thi Hong Chau , Ly 1 1 1 4,5 4,5 1 Van Chuong , Pham Phu Loc , Dinh Xuan Sinh , Arjen Dondorp , Nicholas White , Tran Tinh Hien , Nicholas Day4,5 1 Hospital of Tropical Diseases, Ho Chi Minh City, Vietnam, 2 Cairns Base Hospital, Cairns, Australia, 3 Worldwide Antimalarial Resistance Network, Bangkok, Thailand, 4 Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, 5 Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom Abstract Background: Optimising the fluid resuscitation of patients with severe malaria is a simple and potentially cost-effective intervention. Current WHO guidelines recommend central venous pressure (CVP) guided, crystalloid based, resuscitation in adults. Methods: Prospectively collected haemodynamic data from intervention trials in Vietnamese adults with severe malaria were analysed retrospectively to assess the responses to fluid resuscitation. Results: 43 patients were studied of whom 24 received a fluid load. The fluid load resulted in an increase in cardiac index (mean increase: 0.75 L/min/m2 (95% Confidence interval (CI): 0.41 to 1.1)), but no significant change in acid-base status post resuscitation (mean in