a role for central nervous growth hormone-releasing hormone signaling in the consolidation of declarative memories中枢神经生长激素释放激素信号的作用在陈述性记忆的巩固.pdfVIP

A Role for Central Nervous Growth Hormone-Releasing Hormone Signaling in the Consolidation of Declarative Memories 1. 1. 2 1,2 3 Manfred Hallschmid *, Ines Wilhelm , Christian Michel , Boris Perras , Jan Born ¨ ¨ ¨ ¨ 1 Department of Neuroendocrinology, University of Lubeck, Lubeck, Germany, 2 Department of Internal Medicine I, University of Lubeck, Lubeck, Germany, 3 Department ¨ ¨ of Medical Psychology and Behavioral Neurobiology, University of Tubingen, Tubingen, Germany Abstract Contributions of somatotropic hormonal activity to memory functions in humans, which are suggested by clinical observations, have not been systematically examined. With previous experiments precluding a direct effect of systemic growth hormone (GH) on acute memory formation, we assessed the role of central nervous somatotropic signaling in declarative memory consolidation. We examined the effect of intranasally administered growth hormone releasing- hormone (GHRH; 600 mg) that has direct access to the brain and suppresses endogenous GHRH via an ultra-short negative feedback loop. Twelve healthy young men learned word-pair associates at 2030 h and were administered GHRH and placebo, respectively, at 2100 h. Retrieval was tested after 11 hours of wakefulness. Compared to placebo, intranasal GHRH blunted GH release within 3 hours after substance administration and reduced the number of correctly recalled word-pairs by ,12% (both P,0.05). The imp