有哪些信誉好的足球投注网站a role for mesenchyme dynamics in mouse lung branching morphogenesis一个角色在小鼠肺间质动力学分支形态发生.pdfVIP
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a role for mesenchyme dynamics in mouse lung branching morphogenesis一个角色在小鼠肺间质动力学分支形态发生
A Role for Mesenchyme Dynamics in Mouse Lung
Branching Morphogenesis
1,2 1,5 3 ¨ 4 ¨ 1 1,6
Pierre Blanc *, Karen Coste , Pierre Pouchin , Jean-Marc Azaıs , Loıc Blanchon , Denis Gallot ,
Vincent Sapin1,2
1 Retinoids, Development and Developmental Diseases – EA 7281, Medicine School, Auvergne University, Clermont-Ferrand, France, 2 Department of Biochemistry and
Molecular Biology, University Hospital, Clermont-Ferrand, France, 3 GReD, CNRS 6247, INSERM 1103, UMR, Clermont University, Clermont-Ferrand, France, 4 Mathematic
Institute, Toulouse III University, Toulouse, France, 5 Department of Pediatrics, University Hospital, Clermont-Ferrand, France, 6 Department of Obstetrics, University
Hospital, Clermont-Ferrand, France
Abstract
Mammalian airways are highly ramified tree-like structures that develop by the repetitive branching of the lung epithelium
into the surrounding mesenchyme through reciprocal interactions. Based on a morphometric analysis of the epithelial tree,
it has been recently proposed that the complete branching scheme is specified early in each lineage by a programme using
elementary patterning routines at specific sites and times in the developing lung. However, the coupled dynamics of both
the epithelium and mesenchyme have been overlooked in this process. Using a qualitative and quantitative in vivo
morphometric analysis of the E11.25 to E13.5 mouse whole right cranial lobe structure, we show that beyond the first
generations, the branching stereotypy relaxes and both spatial and temporal variations are common. The branching pattern
and branching rate are sensitive to the dynamic chan
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