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a smart mutation scheme produces hundreds of functional proteins智能突变计划产生数以百计的功能蛋白质
Synopses of Research Articles
A Smart Mutation Scheme Produces Hundreds of Functional Proteins
Richard Robinson | DOI: 10.1371/journal.pbio.0040136
A protein’s structure dictates its proteins. Detailed analysis revealed the
function, and one of the most direct contribution to catalytic activity of a
and powerful ways to explore a previously unappreciated amino acid
protein’s function is by modifying near the enzyme’s active site. Some
its structure. Such an exploration of the mutants were more resistant to
is carried out naturally every time a heat degradation than the originals,
protein’s gene is mutated, and the indicating the potential for creating
same process can be mimicked in the novel and possibly useful new variants
lab. Unfortunately, approaches that using this method.
introduce random mutations frequently The mutation method used here
disrupt the interactions that keep a increased the yield of properly folded
protein properly folded, rendering cytochromes by 10,000-fold over
the mutant entirely functionless DOI: 10.1371/journal.pbio.0040136.g001 entirely random mutation techniques,
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