a systematic analysis of cell cycle regulators in yeast reveals that most factors act independently of cell size to control initiation of division在酵母细胞周期调控的系统分析表明,大多数因素独立行动的细胞大小来控制启动.pdfVIP

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a systematic analysis of cell cycle regulators in yeast reveals that most factors act independently of cell size to control initiation of division在酵母细胞周期调控的系统分析表明,大多数因素独立行动的细胞大小来控制启动.pdf

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a systematic analysis of cell cycle regulators in yeast reveals that most factors act independently of cell size to control initiation of division在酵母细胞周期调控的系统分析表明,大多数因素独立行动的细胞大小来控制启动

A Systematic Analysis of Cell Cycle Regulators in Yeast Reveals That Most Factors Act Independently of Cell Size to Control Initiation of Division 1 1 1 1 1 Scott A. Hoose , Jeremy A. Rawlings , Michelle M. Kelly , M. Camille Leitch , Qotaiba O. Ababneh , 1 1 1 1 1 Juan P. Robles , David Taylor , Evelyn M. Hoover , Bethel Hailu , Kayla A. McEnery , S. Sabina 1 1 1 1 1 2 Downing , Deepika Kaushal , Yi Chen , Alex Rife , Kirtan A. Brahmbhatt , Roger Smith III , Michael Polymenis1* 1 Department of Biochemistry and Biophysics, Texas AM University, College Station, Texas, United States of America, 2 Department of Veterinary Pathobiology, Texas AM University, College Station, Texas, United States of America Abstract Upstream events that trigger initiation of cell division, at a point called START in yeast, determine the overall rates of cell proliferation. The identity and complete sequence of those events remain unknown. Previous studies relied mainly on cell size changes to identify systematically genes required for the timely completion of START. Here, we evaluated panels of non-essential single gene deletion strains for altered DNA content by flow cytometry. This analysis revealed that most gene deletions that altered cell cycle progression did not change cell size. Our results highlight a strong requirement for ribosomal biogenesis and protein synthesis for initiation of cell division. We also identified numerous factors that have not been previously implicated in cell cycle c