a systematic review of studies that aim to determine which outcomes to measure in clinical trials in children系统回顾研究旨在确定的结果来衡量儿童临床试验中.pdfVIP
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a systematic review of studies that aim to determine which outcomes to measure in clinical trials in children系统回顾研究旨在确定的结果来衡量儿童临床试验中
PLoS MEDICINE
A Systematic Review of Studies That Aim to
Determine Which Outcomes to Measure in
Clinical Trials in Children
1* 1 1 2
Ian Sinha , Leanne Jones , Rosalind L. Smyth , Paula R. Williamson
1 Institute of Child Health, University of Liverpool, Liverpool, United Kingdom, 2 Centre for Medical Statistics and Health Evaluation, University of Liverpool, Liverpool, United
Kingdom
Funding: Ian Sinha is funded by the A B S T R A C T
Department of Health. The funders
had no role in study design, data
collection and analysis, decision to
publish or preparation of the Background
manuscript.
In clinical trials the selection of appropriate outcomes is crucial to the assessment of whether
Competing Interests: The authors one intervention is better than another. Selection of inappropriate outcomes can compromise
have declared that no competing the utility of a trial. However, the process of selecting the most suitable outcomes to include
interests exist.
can be complex. Our aim was to systematically review studies that address the process of
Academic Editor: David Moher, selecting outcomes or outcome domains to measure in clinical trials in children.
Children’s Hospital of Eastern
Ontario Research Institute, Canada
Methods and Findings
Citation: Sinha I, Jones L, Smyth RL,
Williamson PR (2008) A systematic We searched Cochrane databases (no date restrictions) in December 2006; and MEDLINE
review of studies that aim to
determine which outcomes to (1950 to 2006), CINAHL (
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