a systems genetics approach provides a bridge from discovered genetic variants to biological pathways in rheumatoid arthritis系统遗传学的方法提供了一个桥从发现基因变异的生物学通路在类风湿性关节炎.pdfVIP
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a systems genetics approach provides a bridge from discovered genetic variants to biological pathways in rheumatoid arthritis系统遗传学的方法提供了一个桥从发现基因变异的生物学通路在类风湿性关节炎
A Systems Genetics Approach Provides a Bridge from
Discovered Genetic Variants to Biological Pathways in
Rheumatoid Arthritis
1 2 2,3 2 2 4
Hirofumi Nakaoka , Tailin Cui , Atsushi Tajima , Akira Oka , Shigeki Mitsunaga , Koichi Kashiwase ,
5 6 6 2 1,2
Yasuhiko Homma , Shinji Sato , Yasuo Suzuki , Hidetoshi Inoko , Ituro Inoue *
1 Division of Human Genetics, Department of Integrated Genetics, National Institute of Genetics, Mishima, Shizuoka, Japan, 2 Division of Molecular Life Science, School of
Medicine, Tokai University, Isehara, Kanagawa, Japan, 3 Department of Human Genetics and Public Health, Institute of Health Biosciences, The University of Tokusima
Graduate School, Tokushima, Tokushima, Japan, 4 Department of Laboratory, Japanese Red Cross Tokyo Blood Center, Koto-ku, Tokyo, Japan, 5 Department of Clinical
Health Science, Tokai University School of Medicine, Isehara, Kanagawa, Japan, 6 Department of Internal Medicine, Division of Rheumatology, Tokai University School of
Medicine, Isehara, Kanagawa, Japan
Abstract
Genome-wide association studies (GWAS) have yielded novel genetic loci underlying common diseases. We propose a
systems genetics approach to utilize these discoveries for better understanding of the genetic architecture of rheumatoid
arthritis (RA). Current evidence of genetic associations with RA was sought through PubMed and the NHGRI GWAS catalog.
The associations of 15 single nucleotide polymorphisms and HLA-DRB1 alleles were confirmed in 1,287 cases and 1,500
controls of Japanese subjects. Among these, HLA-DRB1 alleles and e
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