a televised, web-based randomised trial of an herbal remedy (valerian) for insomnia电视、基于web的随机试验的草药(缬草)失眠.pdfVIP

A Televised, Web-Based Randomised Trial of an Herbal Remedy (Valerian) for Insomnia 1 1 ˚ 1 1 1 1 1 ˚ Andrew D. Oxman *, Signe Flottorp , Kari Havelsrud , Atle Fretheim , Jan Odgaard-Jensen , Astrid Austvoll-Dahlgren , Cheryl Carling , Stale Pallesen2,3, Bjørn Bjorvatn2,4 1 Norwegian Knowledge Centre for the Health Services, Oslo, Norway, 2 Norwegian Competence Center for Sleep Disorders, Haukeland University Hospital, Bergen, Norway, 3 Department of Psychosocial Science, University of Bergen, Bergen, Norway, 4 Section for General Practice, University of Bergen, Bergen, Norway Background. This trial was conducted as part of a project that aims to enhance public understanding and use of research in decisions about healthcare by enabling viewers to participate in research and to follow the process, through television reports and on the web. Valerian is an herbal over-the-counter drug that is widely used for insomnia. Systematic reviews have found inconsistent and inconclusive results about its effects. Methods. Participants were recruited through a weekly nationally televised health program in Norway. Enrolment and data collection were over the Internet. 405 participants who were 18 to 75 years old and had insomnia completed a two week diary-keeping run-in period without treatment and were randomised and mailed valerian or placebo tablets for two weeks. All participants and investigators were blind to treatment until after the analysis was completed. Findings. For the primary outcome of a minimally important improvement in self-reported sleep quality ($0.5 units on a 7 point scale), the difference between the valerian group (29%) and the placebo group (21%) was not statistically significant (difference 7.5%; 95% CI-0.9 to 15.9; p = 0.08). On the global sel