a trivalent virus-like particle vaccine elicits protective immune responses against seasonal influenza strains in mice and ferrets三价病毒样颗粒疫苗引发保护性免疫反应对季节性流感菌株在小鼠和雪貂.pdfVIP
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a trivalent virus-like particle vaccine elicits protective immune responses against seasonal influenza strains in mice and ferrets三价病毒样颗粒疫苗引发保护性免疫反应对季节性流感菌株在小鼠和雪貂
A Trivalent Virus-Like Particle Vaccine Elicits Protective
Immune Responses against Seasonal Influenza Strains in
Mice and Ferrets
1,2 3¤a 1 1,2 3
Ted M. Ross *, Kutub Mahmood , Corey J. Crevar , Kirsten Schneider-Ohrum , Penny M. Heaton ,
Rick A. Bright3¤b
1 Center for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, 2 Department of Microbiology and Molecular Genetics,
University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, 3 Novavax, Inc., Rockville, Maryland, United States of America
Abstract
There is need for improved human influenza vaccines, particularly for older adults who are at greatest risk for severe disease,
as well as to address the continuous antigenic drift within circulating human subtypes of influenza virus. We have
engineered an influenza virus-like particle (VLP) as a new generation vaccine candidate purified from the supernatants of Sf9
insect cells following infection by recombinant baculoviruses to express three influenza virus proteins, hemagglutinin (HA),
neuraminidase (NA), and matrix 1 (M1). In this study, a seasonal trivalent VLP vaccine (TVV) formulation, composed of
influenza A H1N1 and H3N2 and influenza B VLPs, was evaluated in mice and ferrets for the ability to elicit antigen-specific
immune responses. Animals vaccinated with the TVV formulation had hemagglutination-inhibition (HAI) antibody titers
against all three homologous influenza virus strains, as well as HAI antibodies against a panel of heterologous influenza
viruses. HAI titers elicited by the TVV were statistically similar
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