- 1、本文档共15页,可阅读全部内容。
- 2、有哪些信誉好的足球投注网站(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。
- 3、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载。
- 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
- 5、该文档为VIP文档,如果想要下载,成为VIP会员后,下载免费。
- 6、成为VIP后,下载本文档将扣除1次下载权益。下载后,不支持退款、换文档。如有疑问请联系我们。
- 7、成为VIP后,您将拥有八大权益,权益包括:VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 8、VIP文档为合作方或网友上传,每下载1次, 网站将根据用户上传文档的质量评分、类型等,对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
a trigeminoreticular pathway implications in pain疼痛trigeminoreticular通路的影响
A Trigeminoreticular Pathway: Implications in Pain
W. Michael Panneton*, Qi Gan, Robert S. Livergood
Department of Pharmacological and Physiological Science, St. Louis University School of Medicine, St. Louis, Missouri, United States of America
Abstract
Neurons in the caudalmost ventrolateral medulla (cmVLM) respond to noxious stimulation. We previously have shown most
efferent projections from this locus project to areas implicated either in the processing or modulation of pain. Here we show
the cmVLM of the rat receives projections from superficial laminae of the medullary dorsal horn (MDH) and has neurons
activated with capsaicin injections into the temporalis muscle. Injections of either biotinylated dextran amine (BDA) into the
MDH or fluorogold (FG)/fluorescent microbeads into the cmVLM showed projections from lamina I and II of the MDH to the
cmVLM. Morphometric analysis showed the retrogradely-labeled neurons were small (area 88.7 2
mm 63.4) and mostly
fusiform in shape. Injections (20–50 ml) of 0.5% capsaicin into the temporalis muscle and subsequent immunohistochemistry
for c-Fos showed nuclei labeled in the dorsomedial trigeminocervical complex (TCC), the cmVLM, the lateral medulla, and
the internal lateral subnucleus of the parabrachial complex (PBil). Additional labeling with c-Fos was seen in the subnucleus
interpolaris of the spinal trigeminal nucleus, the rostral ventrolateral medulla, the superior salivatory nucleus, the rostral
ventromedial medulla, and the A1, A5, A7 and subcoeruleus catecholamine areas. Injections of FG into the PBil produced
robust label in the lateral medulla and cmVLM while injections of BDA into the lateral medulla showed projections to the
PBil. Immunohistochemical ex
您可能关注的文档
- a research agenda for helminth diseases of humans diagnostics for control and elimination programmes人类寄生虫疾病诊断的研究议程控制和消除项目.pdf
- a research agenda for helminth diseases of humans health research and capacity building in disease-endemic countries for helminthiases control人类的寄生虫疾病的研究议程在疾病流行国家卫生研究和能力建设蠕虫病的控制.pdf
- a research agenda for helminth diseases of humans basic research and enabling technologies to support control and elimination of helminthiases人类寄生虫疾病的研究议程的基础研究和支持技术支持控制和消灭蠕虫病.pdf
- a remarkable case of micro-endemism in laonastes aenigmamus (diatomyidae, rodentia) revealed by nuclear and mitochondrial dna sequence data的情况下在laonastes micro-endemism aenigmamus(diatomyidae啮齿目)揭示了核和线粒体dna序列数据.pdf
- a research agenda for helminth diseases of humans modelling for control and elimination人类造型的研究议程为寄生虫疾病控制和消除.pdf
- a research agenda for helminth diseases of humans social ecology, environmental determinants, and health systems寄生虫疾病的研究议程的人类社会生态学,环境因素和卫生系统.pdf
- a research agenda for malaria eradication basic science and enabling technologies根除疟疾的研究议程基础科学和可行的技术.pdf
- a research agenda for helminth diseases of humans intervention for control and elimination人类干预的研究议程为寄生虫疾病控制和消除.pdf
- a research agenda for helminth diseases of humans towards control and elimination人类的寄生虫疾病的研究议程对控制和消除.pdf
- a research agenda for helminth diseases of humans the problem of helminthiases人类的寄生虫疾病的研究议程蠕虫病的问题.pdf
- 血液系统药—抗贫血药(护用药理学).pptx
- 华福证券-华福固收-利率新低后怎么看.pdf
- 华创证券-顺丰控股-002352-深度研究报告:解码顺丰系列-19-:三个话题聊聊顺丰净利率能否可持续提升.pdf
- 血液系统药(护用药理学课件).pptx
- 华安证券-三美股份-603379-制冷剂进入景气周期,氟材料加速产业链布局.pdf
- 海通证券-前道半导体设备板块24半年报业绩总结.pdf
- 海通证券-美联储降息周期有望开启关注黄金股修复机会.pdf
- 传出神经系统药—肾上腺素受体阻断药(护用药理学).pptx
- 海通证券-高频选股因子周报:大单与买入意愿因子表现回暖,深度与多粒度因子表现稳健.pdf
- 国信证券-资金观察货币瞭望:社融和信贷数据呈现企稳信号9月市场利率预计季节性上行.pdf
文档评论(0)