a unique dual activity amino acid hydroxylase in toxoplasma gondii一个独特的双羟化酶活性氨基酸在刚地弓形虫.pdfVIP
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a unique dual activity amino acid hydroxylase in toxoplasma gondii一个独特的双羟化酶活性氨基酸在刚地弓形虫
A Unique Dual Activity Amino Acid Hydroxylase in
Toxoplasma gondii
1 1 3 2 1
Elizabeth A. Gaskell , Judith E. Smith , John W. Pinney , Dave R. Westhead , Glenn A. McConkey *
1 Institute of Integrative and Comparative Biology, University of Leeds, Leeds, United Kingdom, 2 Institute of Molecular and Cellular Biology, University of Leeds, Leeds,
United Kingdom, 3 Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
Abstract
The genome of the protozoan parasite Toxoplasma gondii was found to contain two genes encoding tyrosine hydroxylase;
that produces L-DOPA. The encoded enzymes metabolize phenylalanine as well as tyrosine with substrate preference for
tyrosine. Thus the enzymes catabolize phenylalanine to tyrosine and tyrosine to L-DOPA. The catalytic domain descriptive of
this class of enzymes is conserved with the parasite enzyme and exhibits similar kinetic properties to metazoan tyrosine
hydroxylases, but contains a unique N-terminal extension with a signal sequence motif. One of the genes, TgAaaH1, is
constitutively expressed while the other gene, TgAaaH2, is induced during formation of the bradyzoites of the cyst stages of
the life cycle. This is the first description of an aromatic amino acid hydroxylase in an apicomplexan parasite. Extensive
searching of apicomplexan genome sequences revealed an ortholog in Neospora caninum but not in Eimeria,
Cryptosporidium, Theileria, or Plasmodium. Possible role(s) of these bi-functional enzymes during host infection are
discussed.
Citation: Gaskell EA, Smith JE, Pinney JW, Westhead DR, McConkey GA (2009) A Unique Dual Activit
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