有哪些信誉好的足球投注网站a vlp vaccine induces broad-spectrum cross-protective antibody immunity against h5n1 and h1n1 subtypes of influenza a virus车牌区域疫苗诱发广谱cross-protective抗体免疫抗h5n1和h1n1甲型流感病毒的亚型.pdfVIP
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a vlp vaccine induces broad-spectrum cross-protective antibody immunity against h5n1 and h1n1 subtypes of influenza a virus车牌区域疫苗诱发广谱cross-protective抗体免疫抗h5n1和h1n1甲型流感病毒的亚型
A VLP Vaccine Induces Broad-Spectrum Cross-Protective
Antibody Immunity against H5N1 and H1N1 Subtypes of
Influenza A Virus
1 1 2 1 1,3,4 4
Chia-Ying Wu , Yi-Chun Yeh , Jia-Tsrong Chan , Yu-Chih Yang , Ji-Rong Yang , Ming-Tsan Liu , Ho-
Sheng Wu4, Pei-Wen Hsiao1,3*
1 Agricultural Biotechnology Research Center, Academia Sinica, Taipei, Taiwan, 2 Genomics Research Center, Academia Sinica, Taipei, Taiwan, 3 Institute of Biotechnology,
College of Bio-Resources and Agriculture, National Taiwan University, Taipei, Taiwan, 4 Centers for Disease Control, Department of Health, Taipei, Taiwan
Abstract
The recent threats of influenza epidemics and pandemics have prioritized the development of a universal vaccine that offers
protection against a wider variety of influenza infections. Here, we demonstrate a genetically modified virus-like particle
(VLP) vaccine, referred to as H5M2eN1-VLP, that increased the antigenic content of NA and induced rapid recall of antibody
against HA2 after viral infection. As a result, H5M2eN1-VLP vaccination elicited a broad humoral immune response against
multiple viral proteins and caused significant protection against homologous RG-14 (H5N1) and heterologous A/California/
07/2009 H1N1 (CA/07) and A/PR/8/34 H1N1 (PR8) viral lethal challenges. Moreover, the N1-VLP (lacking HA) induced
production of a strong NA antibody that also conferred significant cross protection against H5N1 and heterologous CA/07
but not PR8, suggesting the protection against N1-serotyped viruses can be extended from avian-origin to CA/07 strain
isolated in humans, but not to evolutionally distant strains of human-derived. By comparative vaccine study of an HA-based
VLP (H5N1-VLP) and NA-based VLP
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