两种方法治疗糖尿病合并慢性心力衰竭评价.doc

两种方法治疗糖尿病合并慢性心力衰竭评价[摘要] 目的:探讨两种方法治疗糖尿病合并慢性心力衰竭的效果。方法:90例2型糖尿病合并慢性心力衰竭患者随机分为卡维地洛治疗组(A组)45例和常规治疗组(B组)45例。B组采用常规治疗, A组在B组治疗的基础上加服卡维地洛25 mg,2次/d, 比较治疗后两组患者的心率、血压、心脏功能、心脏事件及药物耐受性。结果:A组治疗后LVESVI、LVEDVI、LVEF较治疗前有显著性差异(t=2.231,t=2.311,t=2.351,均P0.05)。结论:卡维地洛治疗糖尿病合并慢性心力衰竭的安全性和有效性明显优于常规治疗。 [关键词] 糖尿病;慢性心力衰竭;卡维地洛;安全性;社区康复 [中图分类号]R587.2 [文献标识码]B [文章编号]1673-7210(2010)03(c)-056-02 Evaluation of diabetic mellitus with chronic heart failure by two treatment methods GUO Naihuo1, QI Huayun2, TANG Tao3 (1.Department of Community Rehabilitation, Longgang Central Hospital of Shenzhen City, Shenzhen 518116, China; 2.Department of Operating Rooms, Longgang Central Hospital of Shenzhen City, Shenzhen 518116, China; 3.Department of General Surgery, Longgang Central Hospital of Shenzhen City, Shenzhen 518116, China) [Abstract] Objective: To investigate the curative effect of diabetic mellitus with chronic heart failure by two treatment methods. Methods: 90 patients of diabetes mellitus with chronic heart failure were randomly divided into Carvedilol treatment (Group A) 45 cases and Conventional treatment (Group B) 45 cases. The Group B with conventional therapy, Group A in the control group based on the added Carvedilol 25 mg, 2 times/d, the heart rate, blood pressure, heart function, cardiac events and drug tolerance in two groups after treatment were compared. Results: The indicators of LVESVI, LVEDVI,LVEF after treatment than before treatment were significantly different in Group A (t=2.231, t=2.311, t=2.351, all P0.05). Conclusion: The safety and effectiveness of Carvedilol treatment were superior than Conventional treatment in diabetes mellitus with chronic heart failure. [Key words] Diabetes mellitus; Chronic heart failure; Carvedilol; Security 传统的β受体阻滞剂可能引起血脂代谢异常、电解质紊乱和血糖代谢障碍等不利作用[1]。卡维地洛是一种新型β受体阻滞剂,能选择性阻滞α1受体扩张血管,非选择性阻滞β1和β2受体的长效降压药,能够改善患者的依从性。为了研究卡维地洛在对传统β受体阻断剂可能产生的不良代谢作用,本研究用卡维地洛治疗糖尿病合并慢性心衰,探讨其安全性和有效性。 1 资料与方法 1.1 一般资料 收集2004年8月～2008年10月在我院住院的糖尿病合并慢性