心脏发育过程中信号调控机制研究.pdf

19 4 Vol. 19, No. 4 2007 8 Chinese Bulletin of Life Sciences Aug., 2007 1004-0374(2007)04-0353-06 · · 2 1 0 0 6 1 [1] [2] ( ) ANF β-MHC [1-2] R541; Q132.4; Q954.4 A Mechanistic study of signal transduction in heart development CHANG Zai, YANG Zhongzhou* (Model Animal Research Center of Nanjing University, Nanjing 210061, China) Abstract: In China, the population quality is deteriorating by high rate of birth defects, among which congenital heart diseases are the most common. Similarly, postnatal cardiovascular disorders are becoming the main impediment to population health and social development. Recent studies have demonstrated that developmen- tal biology is involved in the pathogenesis of postnatal cardiovascular disorders in that hereditary factors contribute to the progress of these diseases, although they fail to cause embryonic abnormalities. The fact that in some postnatal cardiovascular diseases, essential genes for embryogenesis such as ANF and beta-MHC are activated indicates that certain embryonic developmental mechanisms are engaged in the pathogenesis. Be- cause the prevention of birth defects and cardiovascular disorders is one of the major issues that demands urgent solution for public health and social devel