first isolation and direct evidence for the existence of large small-mammal reservoirs of leptospira sp. in madagascar首先隔离和小型哺乳动物存在的直接证据座大型水库的钩端螺旋体sp.马达加斯加.pdfVIP

first isolation and direct evidence for the existence of large small-mammal reservoirs of leptospira sp. in madagascar首先隔离和小型哺乳动物存在的直接证据座大型水库的钩端螺旋体sp.马达加斯加.pdf

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first isolation and direct evidence for the existence of large small-mammal reservoirs of leptospira sp. in madagascar首先隔离和小型哺乳动物存在的直接证据座大型水库的钩端螺旋体sp.马达加斯加

First Isolation and Direct Evidence for the Existence of Large Small-Mammal Reservoirs of Leptospira sp. in Madagascar 1 ´ 2 3 4 3 Soanandrasana Rahelinirina , Albertine Leon , Rudy A. Harstskeerl , Natacha Sertour , Ahmed Ahmed , 1 4 4 ¨ 5 6 Claudine Raharimanana , Elisabeth Ferquel , Martine Garnier , Loıc Chartier , Jean-Marc Duplantier , Lila Rahalison1, Muriel Cornet4,7* 1 Plague Unit, Pasteur Institute, Antananarivo, Madagascar, 2 Frank Duncombe Laboratory, IFR 146 ICORE, Caen, France, 3 WHO/FAO/OIE and National Leptospirosis Reference Centre, KIT Biomedical Research, Amsterdam, The Netherlands, 4 National Reference Centre for Borrelia, Pasteur Institute, Paris, France, 5 Epidemiology Unit, Pasteur Institute, Paris, France, 6 IRD, UMR CBGP (INRA/IRD/Cirad/Montpellier SupAgro), Montferrier-sur-Lez, France, 7 Parasitology-Mycology Laboratory, CHU Grenoble, University Joseph Fourier, Grenoble, France Abstract Background: Leptospirosis has long been a major public health concern in the southwestern Indian Ocean. However, in Madagascar, only a few, old studies have provided indirect serological evidence of the disease in humans or animals. Methodology/Principal Findings: We conducted a large animal study focusing on small-mammal populations. Five field trapping surveys were carried out at five sites, from April 2008 to August 2009. Captures consisted of Rattus norvegicus (35.8%), R. rattus (35.1%), Mus musculus (20.5%) and Suncus murinus (8.6%). We used microbio

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