first qualification study of serum biomarkers as indicators of total body burden of osteoarthritis第一次资格研究血清生物标志物指标的全身骨关节炎的负担.pdfVIP
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first qualification study of serum biomarkers as indicators of total body burden of osteoarthritis第一次资格研究血清生物标志物指标的全身骨关节炎的负担
First Qualification Study of Serum Biomarkers as
Indicators of Total Body Burden of Osteoarthritis
1 . 2. 1 3 3
Virginia B. Kraus * , Thomas B. Kepler , Thomas Stabler , Jordan Renner , Joanne Jordan
1 Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America, 2 Department of Biostatistics and Bioinformatics and
Department of Immunology, Duke University Medical Center, Durham, North Carolina, United States of America, 3 Thurston Arthritis Research Center, University of North
Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
Abstract
Background: Osteoarthritis (OA) is a debilitating chronic multijoint disease of global proportions. OA presence and severity
is usually documented by x-ray imaging but whole body imaging is impractical due to radiation exposure, time and cost.
Systemic (serum or urine) biomarkers offer a potential alternative method of quantifying total body burden of disease but
no OA-related biomarker has ever been stringently qualified to determine the feasibility of this approach. The goal of this
study was to evaluate the ability of three OA-related biomarkers to predict various forms or subspecies of OA and total body
burden of disease.
Methodology/Principal Findings: Female participants (461) with clinical hand OA underwent radiography of hands, hips,
knees and lumbar spine; x-rays were comprehensively scored for OA features of osteophyte and joint space narrowing.
Three OA-related biomarkers, serum hyaluronan (sHA), cartilage oligomeric matrix protein (sCOMP), and urinary C-
telopeptide of type II collagen (uCTX2), were measured by ELISA. sHA, sCOMP a
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