functional impairment of human myeloid dendritic cells during schistosoma haematobium infection人类骨髓树突状细胞功能障碍在埃及血吸虫感染.pdfVIP

Functional Impairment of Human Myeloid Dendritic Cells during Schistosoma haematobium Infection 1 1,2,3 1 1 2,3 Bart Everts *, Ayola A. Adegnika , Yvonne C. M. Kruize , Hermelijn H. Smits , Peter G. Kremsner , Maria Yazdanbakhsh1 ¨ ¨ 1 Department of Parasitology, Leiden University Medical Centre, Leiden, The Netherlands, 2 Institute of Tropical Medicine, University of Tubingen, Tubingen, Germany, ´ ´ 3 Medical Research Unit, Albert Schweitzer Hospital, Lambarene, Gabon Abstract Chronic Schistosoma infection is often characterized by a state of T cell hyporesponsiveness of the host. Suppression of dendritic cell (DC) function could be one of the mechanisms underlying this phenomenon, since Schistosoma antigens are potent modulators of dendritic cell function in vitro. Yet, it remains to be established whether DC function is modulated during chronic human Schistosoma infection in vivo. To address this question, the effect of Schistosoma haematobium infection on the function of human blood DC was evaluated. We found that plasmacytoid (pDC) and myeloid DC (mDC) from infected subjects were present at lower frequencies in peripheral blood and that mDC displayed lower expression levels of HLA-DR compared to those from uninfected individuals. Furthermore, mDC from infected subjects, but not pDC, were found to have a reduced capacity to respond